منابع مشابه
TATA Box Mimicry by TFIID Autoinhibition of Pol II Transcription
TATA Box Mimicry by TFIID: Minireview Autoinhibition of Pol II Transcription with formation of a stable TBP-TATA element complex. Deletion studies with dTAF II 230 mapped the autoinhibi-tory activity to the first 81 amino acids (reviewed in Liu In eukaryotes, RNA polymerase II (pol II) is responsible for transcribing nuclear genes encoding the messenger RNAs and several small nuclear RNAs. Like...
متن کاملWheat TFIID TATA binding protein.
Using the cDNA clone for yeast TATA binding protein (TBP) (1) we have isolated a cDNA coding for wheat TBP from a wheat seedling cDNA library. Wheat TBP is 201 amino acids (wh, Figure 1). Comparison to other plant TBPs (Figure 1) indicates short, and moderately conserved, amino terminal domains. Dictyostelium also has a short amino domain, but it diverges from those of plants. In contrast the c...
متن کاملFunctional binding of the "TATA" box binding component of transcription factor TFIID to the -30 region of TATA-less promoters.
Many viral and cellular promoters transcribed in higher eukaryotes by RNA polymerase II lack obvious A+T-rich sequences, called "TATA" boxes, that bind the transcription factor TFIID. One such TATA-less promoter, the simian virus 40 major late promoter, contains a genetically important sequence element 30 base pairs upstream of its transcription initiation site that has no obvious sequence simi...
متن کاملIdentification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIID tau).
Previous studies have indicated that human transcription initiation factor TFIID is a large complex that contains a TATA-binding polypeptide (TFIID tau or TBP) and other components that qualitatively alter promoter interactions and are uniquely required for activator-dependent (versus basal) transcription. TFIID tau-specific antibody columns have been employed to identify a number of human TFII...
متن کاملThinking outside the TATA box.
When I was doing my PhD research, in the middle of the last century, the nature and complexity of the RNA transcripts of the genome was a topic of lively debate, into which my own work became drawn. The complexity of the mRNA population in a given tissue, celltype or developmental stage—considered as transcripts that were polyadenylated and associated with ribosomes—was estimated to represent s...
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ژورنال
عنوان ژورنال: Cell
سال: 1998
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81596-2